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1

The effect of TAT conjugated platinum nanoparticles on lifespan in a nematode Caenorhabditis elegans model

Juewon Kim, Takuji Shirasawa, Yusei Miyamoto

Journal:

Year:

2010

Language:

english

File:

PDF, 527 KB

english, 2010

2

Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice

Takahashi, Kazuhide, Noda, Yoshihiro, Ohsawa, Ikuroh, Shirasawa, Takuji, Takahashi, Mayumi

Journal:

Experimental Gerontology

Year:

2014

Language:

english

File:

PDF, 890 KB

english, 2014

3

Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study

Konno, Hiroyuki, Kanai, Yoshiaki, Katagiri, Mikiyuki, Watanabe, Tami, Mori, Akemi, Ikuta, Tomoki, Tani, Hiroko, Fukushima, Shinobu, Tatefuji, Tomoki, Shirasawa, Takuji

Journal:

Evidence-based Complementary and Alternative Medicine

Year:

2013

Language:

english

File:

PDF, 742 KB

english, 2013

4

Influence of Oxidative Stress on D-Aspartyl Endopeptidase Activity

Tadatoshi Kinouchi, Akina Matsuda, Satoru Kawakami, Takahiko Shimizu, Takuji Shirasawa, Noriko Fujii

Journal:

Chemistry & Biodiversity

Year:

2010

Language:

english

File:

PDF, 151 KB

english, 2010

5

Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans

Juewon Kim, Mayumi Takahashi, Takahiko Shimizu, Takuji Shirasawa, Masashi Kajita, Atsuhiro Kanayama, Yusei Miyamoto

Journal:

Mechanisms of Ageing and Development

Year:

2008

Language:

english

File:

PDF, 1.02 MB

english, 2008

6

Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative

Kazuma Murakami, Jun Inagaki, Mitsuru Saito, Yasutaka Ikeda, Chizuru Tsuda, Yoshihiro Noda, Satoru Kawakami, Takuji Shirasawa, Takahiko Shimizu

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 464 KB

english, 2009

7

Age and Sex-Dependent Alterations in Heart Rate Variability

Yukishita, Takehiko, Lee, Keiko, Kim, Sungdo, Yumoto, Yu, Kobayashi, Akiko, Shirasawa, Takuji, Kobayashi, Hiroyuki

Journal:

ANTI-AGING MEDICINE

Year:

2010

Language:

english

File:

PDF, 2.43 MB

english, 2010

8

N-acetyl glucosamine and proteoglycan containing supplement improves the locomotor functions of subjects with knee pain

Naraoka, Yuna, Harada, Hiroshi, Katagiri, Mikiyuki, Yamamura, Haruo, Shirasawa, Takuji

Journal:

Drug Discoveries & Therapeutics

Year:

2017

Language:

english

File:

PDF, 598 KB

english, 2017

9

Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice

Yu, Yang, Shintani, Takafumi, Takeuchi, Yasushi, Shirasawa, Takuji, Noda, Masaharu

Journal:

Journal of Neuroscience

Year:

2018

Language:

english

File:

PDF, 7.03 MB

english, 2018

10

In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization

Takahashi, Kazuhide, Miura, Yuri, Ohsawa, Ikuroh, Shirasawa, Takuji, Takahashi, Mayumi

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 5.67 MB

english, 2018

11

Synthesis of basement membrane by gastrointestinal cancer cell lines

Akashi, Takumi, Miyagi, Tizuko, Ando, Noboru, Suzuki, Yoshimi, Nemoto, Tetsuo, Eishi, Yoshinobu, Nakamura, Kyoichi, Shirasawa, Takuji, Osa, Natsumi, Tanaka, Noboru, Burgeson, Robert E.

Journal:

The Journal of Pathology

Year:

1999

Language:

english

File:

PDF, 529 KB

english, 1999

12

Crystallization and preliminary cryogenic X-ray diffraction analyses of protein L-isoaspartyl O-methyltransferase from human fetal brain

Craig D. Smith, Joseph Barchue, Charles Mentel, Lawrence Delucas, Takuji Shirasawa, Debasish Chattopadhyay

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1997

Language:

english

File:

PDF, 39 KB

english, 1997

13

Differentiating α- and β-aspartic acids by electrospray ionization and low-energy tandem mass spectrometry

Luis Javier González, Takahiko Shimizu, Yoshinori Satomi, Lazaro Betancourt, Vladimir Besada, Gabriel Padrón, Ron Orlando, Takuji Shirasawa, Yasutsugu Shimonishi, Toshifumi Takao

Journal:

Rapid Communications in Mass Spectrometry

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

14

Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1

Mitsunari Nakajima, Takahiko Shimizu, Takuji Shirasawa

Journal:

Journal of Neuroscience Research

Year:

2000

Language:

english

File:

PDF, 296 KB

english, 2000

15

Gene expression of CD24 core peptide molecule in developing brain and developing non-neural tissues

Dr. Takuji Shirasawa, Takumi Akashi, Kyoichi Sakamoto, Hiroshi Takahashi, Naoki Maruyama, Katsuiku Hirokawa

Journal:

Developmental Dynamics

Year:

1993

Language:

english

File:

PDF, 1.66 MB

english, 1993

16

Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

Yuichi Masuda, Satoko Uemura, Ryutaro Ohashi, Azusa Nakanishi, K. Takegoshi, Takahiko Shimizu, Takuji Shirasawa, Kazuhiro Irie

Journal:

Year:

2009

Language:

english

File:

PDF, 641 KB

english, 2009

17

ChemInform Abstract: anti-Aging Research Using Mn-SOD Conditional Knockout Mice

Takahiko Shimizu, Takuji Shirasawa

Journal:

Year:

2010

File:

PDF, 23 KB

2010

18

Presenilin 1 is essential for cardiac morphogenesis

Mitsunari Nakajima, Eiko Moriizumi, Haruhiko Koseki, Takuji Shirasawa

Journal:

Developmental Dynamics

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

19

B cell precursors are present in the thymus during early development

Hiroshi Kimoto, Takuji Shirasawa, Masaru Taniguchi, Toshitada Takemori

Journal:

European Journal of Immunology

Year:

1989

Language:

english

File:

PDF, 1.28 MB

english, 1989

20

Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice

Yuji Ikegaya, Mitsunori Yamada, Tetsuya Fukuda, Hidehito Kuroyanagi, Takuji Shirasawa, Nobuyoshi Nishiyama

Journal:

Year:

2001

Language:

english

File:

PDF, 868 KB

english, 2001

21

Expression of an endogenous retroviral gene product in human placenta

Masanori Kitamura, Naoki Maruyama, Takuji Shirasawa, Ryuji Nagasawa, Kazutada Watanabe, Masatoshi Tateno, Takashi Yoshiki

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 601 KB

english, 1994

22

Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking

Hidetoshi Nojiri, Yoshitomo Saita, Daichi Morikawa, Keiji Kobayashi, Chizuru Tsuda, Tsuyoshi Miyazaki, Mitsuru Saito, Keishi Marumo, Ikuho Yonezawa, Kazuo Kaneko, Takuji Shirasawa, Takahiko Shimizu

Journal:

Journal of Bone and Mineral Research

Year:

2011

Language:

english

File:

PDF, 976 KB

english, 2011

23

Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B Patients: Spontaneous seroconversion and interferon-induced seroconversion

Tatsunobu Karasawa, Yoshio Aizawa, Mikio Zeniya, Akira Kuramoto, Gotaro Toda, Takuji Shirasawa

Journal:

Journal of Medical Virology

Year:

1995

Language:

english

File:

PDF, 860 KB

english, 1995

24

Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice

Midori Ogawara, Mayumi Takahashi, Takahiko Shimizu, Mitsunari Nakajima, Yasuhiro Setoguchi, Takuji Shirasawa

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 2.22 MB

english, 2002

25

Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency

Takahiko Shimizu, Takashi Ikegami, Midori Ogawara, Yo-ichi Suzuki, Mayumi Takahashi, Hidenori Morio, Takuji Shirasawa

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 4.17 MB

english, 2002

26

Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease

Takahiko Shimizu, Hiroyuki Fukuda, Shigeo Murayama, Naoki Izumiyama, Takuji Shirasawa

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 1.95 MB

english, 2002

27

Tissue hyperoxygenation promotes oxidative metabolism in motor unit

Fei Huang, Takahiko Shimizu, Akihiko Ishihara, Shigeki Yuasa, Kinya Nishimura, Toyoki Kugimiya, Takuji Shirasawa

Journal:

Journal of Neuroscience Research

Year:

2005

Language:

english

File:

PDF, 664 KB

english, 2005

28

Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis

Yosuke Shimojo, Kunio Kosaka, Yoshihiro Noda, Takahiko Shimizu, Takuji Shirasawa

Journal:

Journal of Neuroscience Research

Year:

2010

Language:

english

File:

PDF, 385 KB

english, 2010

29

Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation

Toru Sasaki, Takahiko Shimizu, Tomoko Koyama, Masanobu Sakai, Satoshi Uchiyama, Satoru Kawakami, Yoshihiro Noda, Takuji Shirasawa, Shuji Kojima

Journal:

Journal of Neuroscience Research

Year:

2011

Language:

english

File:

PDF, 590 KB

english, 2011

30

Verification of the turn at positions 22 and 23 of the β-amyloid fibrils with Italian mutation using solid-state NMR

Yuichi Masuda, Kazuhiro Irie, Kazuma Murakami, Hajime Ohigashi, Ryutaro Ohashi, K. Takegoshi, Takahiko Shimizu, Takuji Shirasawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 501 KB

english, 2005

31

Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals

Yuichi Masuda, Satoko Uemura, Azusa Nakanishi, Ryutaro Ohashi, K. Takegoshi, Takahiko Shimizu, Takuji Shirasawa, Kazuhiro Irie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 454 KB

english, 2008

32

Synthesis, aggregation, and neurotoxicity of the alzheimer's Aß1-42 amyloid peptide and its isoaspartyl isomers

Hiroyuki Fukuda, Takahiko Shimizu, Mitsunari Nakajima, Hiroshi Mori, Takuji Shirasawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 321 KB

english, 1999

33

Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro

Mitsunari Nakajima, Masami Miura, Toshihiko Aosaki, Takuji Shirasawa

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 657 KB

english, 2001

34

Effect of Ganoderma lucidum extract on adipocyte differentiation and adiponectin gene expression in the murine pre-adipocyte cell line, 3T3-L1

Yosuke Shimojo, Kunio Kosaka, Takuji Shirasawa

Journal:

Phytotherapy Research

Year:

2011

Language:

english

File:

PDF, 411 KB

english, 2011

35

Association between frequency of amino acid changes in core region of hepatitis B virus (HBV) and the presence of precore mutation in Japanese HBV carriers

Tatsunobu Karasawa, Takuji Shirasawa, Yasuhiko Okawa, Akira Kuramoto, Noritomo Shimada, Yoshio Aizawa, Mikio Zeniya, Gotaro Toda

Journal:

Journal of Gastroenterology

Year:

1997

Language:

english

File:

PDF, 1016 KB

english, 1997

36

Aβ species, including IsoAsp23 Aβ, in Iowa-type familial cerebral amyloid angiopathy

Youngah Shin, Hyun Cho, Hiroaki Fukumoto, Takahiko Shimizu, Takuji Shirasawa, Steven M. Greenberg, William G. Rebeck

Journal:

Acta Neuropathologica

Year:

2003

Language:

english

File:

PDF, 511 KB

english, 2003

37

Accelerated acquisition of permeability barrier function in the skin of presenilin-1-deficient embryos

Mitsunari Nakajima, Minetaro Ogawa, Yuri Shimoda, Haruhiko Koseki, Takuji Shirasawa, Kiyoshi Furukawa

Journal:

Archives of Dermatological Research

Year:

2007

Language:

english

File:

PDF, 529 KB

english, 2007

38

Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its β-catenin-binding region

Mitsunari Nakajima, Minetaro Ogawa, Yuri Shimoda, Shuichi Hiraoka, Midori Iida, Haruhiko Koseki, Takuji Shirasawa, Kiyoshi Furukawa

Journal:

Cell Biology International

Year:

2006

Language:

english

File:

PDF, 236 KB

english, 2006

39

The longevity signals are conserved between mammals and C. elegans

Takuji Shirasawa

Journal:

Geriatrics & Gerontology International

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

40

The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimer's disease

Kazuma Murakami, Yuichi Masuda, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie

Journal:

Geriatrics & Gerontology International

Year:

2010

Language:

english

File:

PDF, 544 KB

english, 2010

41

Model mice for tissue-specific deletion of the manganese superoxide dismutase gene

Takahiko Shimizu, Hidetoshi Nojiri, Satoru Kawakami, Satoshi Uchiyama, Takuji Shirasawa

Journal:

Geriatrics & Gerontology International

Year:

2010

Language:

english

File:

PDF, 623 KB

english, 2010

42

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

Takumi Satoh, Kunio Kosaka, Ken Itoh, Akira Kobayashi, Masayuki Yamamoto, Yosuke Shimojo, Chieko Kitajima, Jiankun Cui, Joshua Kamins, Shu-ichi Okamoto, Masanori Izumi, Takuji Shirasawa, Stuart A. Lip

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 1.37 MB

english, 2008

43

Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells

Yasutaka Ikeda, Shinji Tsuji, Akira Satoh, Masaharu Ishikura, Takuji Shirasawa, Takahiko Shimizu

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 647 KB

english, 2008

44

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

Michael S. Lustgarten, Youngmok C. Jang, Yuhong Liu, Wenbo Qi, Yuejuan Qin, Patricia L. Dahia, Yun Shi, Arunabh Bhattacharya, Florian L. Muller, Takahiko Shimizu, Takuji Shirasawa, Arlan Richardson, H

Journal:

Year:

2011

Language:

english

File:

PDF, 497 KB

english, 2011

45

coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q

Daisuke Nakai, Takahiko Shimizu, Hidetoshi Nojiri, Satoshi Uchiyama, Hideo Koike, Mayumi Takahashi, Katsuiku Hirokawa, Takuji Shirasawa

Journal:

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

46

Beneficial effect of transfusion with low-affinity red blood cells in endotoxemia

Fei Huang, Hidetoshi Nojiri, Takahiko Shimizu, Takuji Shirasawa

Journal:

Transfusion (Wiley)

Year:

2005

Language:

english

File:

PDF, 293 KB

english, 2005

47

Gene transfer of metalloproteinase transin induces aberrant behavior of cultured mesangial cells

Kitamura, Masanori, Shirasawa, Takuji, Maruyama, Naoki

Journal:

Kidney International

Year:

1994

Language:

english

File:

PDF, 814 KB

english, 1994

48

Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-Å resolution and modeling of an isoaspartyl-containing peptide at the active site

Craig D. Smith, Mike Carson, Alan M. Friedman, Matthew M. Skinner, Lawrence Delucas, Laurent Chantalat, Lance Weise, Takuji Shirasawa, Debashish Chattopadhyay

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 1.09 MB

english, 2002

49

Proenzyme Form of Cathepsin L Produced by Thymic Epithelial Cells Promotes Proliferation of Immature Thymocytes in the Presence of IL-1, IL-7, and Anti-CD3 Antibody

Michiyuki Kasai, Takuji Shirasawa, Masanori Kitamura, Kazumi Ishido, Eiki Kominami, Katsuiku Hirokawa

Journal:

Cellular Immunology

Year:

1993

File:

PDF, 638 KB

1993

50

Isolation of cDNA clone encoding rat senescence marker protein-30 (SMP30) and its tissue distribution

Toshiko Fujita, Takuji Shirasawa, Kazumi Uchida, Naoki Maruyama

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1992

Language:

english

File:

PDF, 1.06 MB

english, 1992